Targeting the mucosa: genetically engineered vaccines and mucosal immune responses

Mucosal immune responses to meningococcal conjugate polysaccharide vaccines in infants.

BACKGROUND Serogroup C meningococcal conjugate polysaccharide vaccines have been reported to induce significant serum IgG antibodies and immunologic memory in infants. Because meningococcus is a mucosal pathogen colonizing the nasopharynx, local mucosal immune responses may play an important role in host defense against infection and carriage. We have investigated the mucosal IgA and IgG antibo...

Adjuvants modulating mucosal immune responses or directing systemic responses towards the mucosa.

In developing veterinary mucosal vaccines and vaccination strategies, mucosal adjuvants are one of the key players for inducing protective immune responses. Most of the mucosal adjuvants seem to exert their effect via binding to a receptor/or target cells and these properties were used to classify the mucosal adjuvants reviewed in the present paper: (1) ganglioside receptor-binding toxins (chol...

Mucosal Immune Responses

Genetically engineered immune privileged Sertoli cells

Sertoli cells are immune privileged cells, important for controlling the immune response to male germ cells as well as maintaining the tolerogenic environment in the testis. Additionally, ectopic Sertoli cells have been shown to survive and protect co-grafted cells when transplanted across immunological barriers. The survival of ectopic Sertoli cells has led to the idea that they could be used ...

Against HIV at Systemic and Mucosal Sites Elicit Multifaceted Immune Responses Immunostimulatory DNA-Based Vaccines